Table 2.

Summary estimates of diagnostic power and their 95% confidence intervals.

Subgrupo	Se (95% CI)	Sp (95% CI)	PLR (95% CI)	NLR (95% CI)	DOR (95% CI)	AUC (95% CI)
miRNAs profiling
Single miRNA	0.78 [0.74–0.81]	0.89 [0.85–0.92]	6.8 [5.1–9.1]	0.25 [0.22–0.29]	27 [19–38]	0.89 [0.86–0.92]
miRNA clusters	0.91 [0.86–0.94]	0.92 [0.76–0.97]	10.9 [3.5–34.2]	0.10 [0.06–0.16]	109 [26–465]	0.93 [0.90–0.95]
Regulation modo
Upregulated	0.77 [0.71–0.83]	0.92 [0.86–0.96]	9.7 [5.6–16.9]	0.25 [0.19–0.32]	39 [21–73]	0.90 [0.88–0.93]
Downregulated	0.81 [0.77–0.84]	0.87 [0.82–0.90]	6.1 [4.4–8.5]	0.22 [0.18–0.27]	28 [17–45]	0.90 [0.87–0.92]
Sample size
≥100	0.80 [0.76–0.83]	0.89 [0.85–0.92]	7.2 [5.3–9.7]	0.23 [0.19–0.27]	32 [22–46]	0.91 [0.88–0.93]
<100	0.78 [0.70–0.85]	0.89 [0.81–0.94]	7.4 [4.0–13.8]	0.24 [0.17–0.35]	31 [13–71]	0.90 [0.87–0.92]
Specimen types
Serum	0.79 [0.76–0.82]	0.88 [0.84–0.91]	6.6 [4.8–8.9]	0.23 [0.20–0.27]	28 [19–41]	0.89 [0.86–0.91]
Plasma	0.81 [0.64–0.91]	0.93 [0.87–0.96]	11.0 [5.6–21.2]	0.21 [0.10–0.42]	53 [16–180]	0.95 [0.92–0.96]

Se: sensitivity, Sp specificity, PLR: positive likelihood ratios, NLR: negative likelihood ratios, DOR: diagnostic odds ratio, AUC: area under the curve, CI: confidence interval.