Fig. 3.

Inhibition of cell cycle and MAPK signaling pathways by the combination of PAL and TRA in HNC cells. HNC cells were treated with PAL and/or TRA for 72 h. Cell lysates were prepared and the levels of cyclin B1, E2F1, ERK, p-ERK, Rb, and p-Rb were analyzed by western blotting. The data are representatives of two independent experiments.