Figure 3.

General protein structures of androgen receptor (AR) and AR-V7. Full-length AR contains functional domains: NTD, N terminal domain; DBD, DNA-binding domain; H, hinge region; LBD, ligand-binding domain. General locations of the nuclear localization signal (NLS) and nuclear export signal (NES) are indicated, along with regions of transcriptional activation function (AF)-1 and AF-2 binding sites. AR-V7 contains the NTD and DBD, but alternative splicing of the gene truncates the protein leaving only cryptic exon 3 (CE3) at the C-terminus. Numbers flanking domains indicate the approximate amino acid at that location.