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. 2020 Jul 21;14(2):490. doi: 10.4081/oncol.2020.490

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©Copyright: the Author(s)

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Anti-PD-1/PD-L1 isotypes. IgG1-moAbs containing an Fc region, which can bind cognate receptors on immune effector cells, could induce tumor cell lysis mediated by ADCC as compared to those with IgG4 or a mutated Fc region. aNSCLC, advanced nonsmall- cell lung cancer; ADCC, antibody-dependent cell-mediated cytotoxicity (ADCC); Atezo, atezolizumab; CM, checkmate; G, grade; KN, keynote; Ig, immunoglobulin; ImP, ImPower; moAbs, monoclonal antibodies; Nivo, nivolumab; ORR, overall response rate; OS, overall survival; PD1, programmed cell death 1; PD-L1, programmed cell death ligand 1; Pembro, pembrolizumab; PFS, progressionfree survival; Sq, squamous.