Fig. 1.

Histological and imaging appearances of case8 and it’s results of cloning analysis and IDH gene mutation detection. A The morphology of HE under the microscope, (Ai) the junction of two components of DDCS; (Aii) the chondrosarcoma component; (Aiii) the dedifferentiated component. B Results of clonality analysis. (C, chondrosarcoma component; D, dedifferentiated components; +, treated with HpaII enzyme; −, not digested by HpaII enzyme). Two main peaks were found in both the enzymatic and non enzymatic groups of normal female, There was a significant decrease in short size peak in the enzyme-treat group compared with the non enzyme treat group in both component of DDCS. C Imaging data, the arrow is marked with a double manifestation of calcification and non calcification. (Ci) Coronal CT, (Cii) cross section CT. D shows the result of IDH gene mutation detection, and the arrow marks the mutation site. IDH1 R132S mutation (C > G) was detected in both components; IDH2 mutation was not detected in the two components.