SARS-CoV PLpro
|
Geranylated flavonoids (tomentin A-E) |
IC50 = 5.0–14.4 μM |
fluorogenic peptide Z-RLRGG-AMC |
[54] |
SARS-CoV PLpro
|
Bavachinin |
IC50 = 4.2–38.4 μM |
fluorogenic peptide Z-RLRGG-AMC |
[53] |
Corylifol A Isobavachalcone |
4′-O-methylbavachalcone |
Neobavaisoflavone |
Psoralidin |
SARS-CoV PLpro
|
Papyriflavonol A |
IC50 = 3.7 μM |
fluorogenic peptide Z-RLRGG-AMC |
[55] |
SARS-CoV PLpro
|
Xanthoangelol E |
IC50 = 1.2 μM |
cell-free method |
[58] |
SARS-CoV 3CLpro
|
Xanthoangelol E |
IC50 = 11.4 μM |
cell-free method |
[58] |
IC50 = 7.1 μM |
cell-based method |
SARS-CoV 3CLpro
|
Herbacetin |
IC50 = 33.17 |
recombinant protein; FRET method |
[57] |
Pectolinarin |
IC50 = 27.45 |
Rhoifolin |
IC50 = 37.78 μM |
SARS-CoV 3CLpro
|
Isatis indigotica extract |
IC50 = 53.8 μg/ml |
cell-free method |
[49] |
Hesperetin |
IC50 = 60 μM |
SARS-CoV 3CLpro
|
Quercetin-3-β-galactoside |
IC50 = 42.79 μM |
recombinant protein |
[50] |
SARS-CoV 3CLpro
|
Amentoflavone |
IC50 = 8.3 μM |
recombinant protein; FRET method |
[51] |
SARS-CoV 3CLpro
|
Epigallocatechin gallate |
IC50 = 47–73 μM. |
recombinant protein; FRET method |
[52] |
Gallocatechin gallate |
Quercetin |
MERS-CoV 3CLpro
|
Helichrysetin |
IC50 = 40.59 μM |
recombinant protein FRET method |
[56] |
Herbacetin |
IC50 = 35.85 μM |
Isobavachalcone |
IC50 = 37.03 μM |
Quercetin 3‐β‐D‐glucoside |
IC50 = 67.04 μM |
SARS-CoV NTPase/helicase |
Quercetin |
IC50 = 8.1 μM |
recombinant protein FRET-based dsDNA unwinding assay |
[62] |
SARS-CoV NTPase/helicase |
7-O-arylmethylquercetin derivatives |
IC50 = 2.7–5.2 μM |
recombinant protein FRET-based dsDNA unwinding assay |
[63] |
SARS-CoV NTPase/helicase |
Myricetin |
IC50 = 2.71 μM |
recombinant protein FRET-based dsDNA unwinding assay |
[64] |
ATPase activity |
Scutellarein |
IC50 = 0.86 μM |
ATP hydrolysis colorimetric assay |
N protein |
Catechin gallate |
0.05 μg/ml (40% inhibition) |
quantum dots (QDs)-conjugated RNA oligonucleotide on biochip |
[60] |
Gallocatechin gallate |