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. 2020 Jun 8;5:120. [Version 1] doi: 10.12688/wellcomeopenres.15903.1

Table 2. Most highly weighted features over time for Alzheimer’s disease.

Year -5 Year -4 Year -3 Year -2 Year -1
1 GP Home Visit (0.053) Memory loss codes
(0.057)
Memory loss codes
(0.080)
Memory loss codes (0.128) Memory loss codes (0.309)
2 Is a smoker (0.049) GP Home visit (0.050) GP Home visit (0.044) GP Home visit (0.041) Referral to Psychiatrist
Neurologist or Geriatrician
(0.080)
3 Infections (0.044) Infections (0.046) Visit to Emergency
Dept (0.042)
Visit to Emergency Dept
(0.036)
Cognitive Screening
(MMSE) (0.052)
4 Visit to Emergency
Dept (0.043)
Visit to Emergency
Dept (0.042)
Infections (0.038) Dressing of wound, burns
or ulcer (0.035)
Referral to memory
assessment service (0.030)
5 Dressing of wounds,
burns or ulcer (0.038)
Is a smoker (0.041) Dressing of wound,
burns or ulcer (0.036)
Is a smoker (0.034) Antidepressants (0.021)
6 Antipsychotics (0.038) Antipsychotics (0.038) Hospital admission
(0.036)
Infections (0.033) Alzheimer-specific
medication (0.021)
7 Memory Loss Codes
(0.036)
Dressing of wounds,
burns or ulcer (0.035)
Is a smoker (0.032) Hospital admission (0.032) Visit to Emergency Dept
(0.019)
8 Hospital Admission
(0.034)
Hospital admission
(0.033)
Antipsychotics
(0.035)
Antipsychotics (0.032) Did not attend (0.019)
9 Antidepressants
(0.033)
Deafness (0.030) Urinary Tract Infection
(0.033)
Deafness (0.029) Infections (0.018)
10 Urinary tract infection
(0.031)
Chronic kidney disease
(0.030)
Deafness (0.030) Urinary tract infection
(0.028)
Hospital Admission (0.018)
11 Did not attend (0.031) Did not attend (0.029) Chronic Kidney
Disease (0.027)
Did not attend (0.026) GP home visit (0.017)
12 Z-drugs (for insomnia)
(0.028)
Urinary Tract Infection
(0.027)
Did not attend (0.027) Chronic kidney disease
(0.026)
Is a smoker (0.017)
13 Deafness (0.027) Constipation (0.026) Hypertension (0.025) Constipation (0.024) Cognitive Decline (0.017)
14 Chronic Kidney
Disease (0.025)
Antidepressants
(0.024)
Falls (0.023) Hypertension (0.023) Urinary Tract Infection
(0.017)
15 Constipation (0.024) Hypertension (0.023) Constipation (0.022) Antidepressants (0.022) Dressing of wound, burn or
ulcer (0.016)

Key: Red – long standing condition or risk factor; Orange – could be associated with increasing frailty or prodromal dementia symptoms; Green – GP has detected dementia symptoms.

Values for each predictor represent its relative contribution to the model compared to all other predictors (with all predictors together summing to 1.0, and a larger value being assigned to more important predictors; 77 predictors were included).