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Metabolic Stability of Eis Inhibitors
| inhibitor | human | mouse |
|---|---|---|
| 6a | 23 ± 21a | 53 ± 5 |
| 7a | 36 ± 24 | 38 ± 16 |
| 4c | 31 ± 4 | 99 ± 0 |
| 5c | 7 ± 5 | 52 ± 21 |
| 7c | 22 ± 2 | 47 ± 25 |
| 4d | 38 ± 6 | 99 ± 0 |
| 6d | 20 ± 2 | 62 ± 16 |
| 7e | 38 ± 4 | 75 ± 3 |
| 7h | 47 ± 5 | 58 ± 4 |
| 6i | 100 ± 0 | 100 ± 0 |
| 7i | 94 ± 7 | 100 ± 0 |
The values in the table are % metabolized compound after a 30 min incubation with microsomes. The data are the mean ± standard deviation for a minimum of three samples (except 4d, which was tested in duplicates).
