Table 1.
Main histological patterns and key immunophenotypic/molecular markers in oesophageal sarcomas
| Tumour type | Histologic pattern | Immunohistochemical/molecular markers |
| GIST | Spindle cell | KIT |
| DOG1 | ||
| WDLS DDLS | Adipocytic | MDM2 |
| Spindle cell | CDK4 | |
| Pleomorphic | p16 | |
| MLS | Myxoid | S100 |
| Round cell | t (12; 16) (q13; p11): FUS-DDIT3 | |
| PLS | Pleomorphic | S100 |
| MPNST | Spindle cell | S100 |
| SOX10 | ||
| PEComa | Epithelioid | Melan A |
| Spindle cell | HMB45 | |
| Smooth muscle actin | ||
| Desmin | ||
| Solitary fibrous tumour | Spindle cell | STAT6 |
| CD34 | ||
| Leiomyosarcoma | Spindle cell | Smooth muscle actin |
| Myxoid | ||
| Desmin | ||
| Epithelioid | ||
| Synovial sarcoma | Spindle cell | EMA |
| Cytokeratins | ||
| CD99 | ||
| TLE-1 | ||
| t (X; 18) (p 11.2; q 11.2) SYT-SSX | ||
| Kaposi sarcoma | Spindle cell | HHV-8 |
| CD31 | ||
| CD34 | ||
| ERG | ||
| Angiosarcoma | Epithelioid | CD31 |
| Spindle cell | CD34 | |
| ERG | ||
| Ewing sarcoma | Round cell | CD99 |
| FLI-1 | ||
| t (11; 22) (q24; q12): EWSR1-FLI1 |
GIST: Gastrointestinal stromal tumour; WDLS: Well-differentiated liposarcoma; DDLS: Dedifferentiated liposarcoma; MLS: Myxoid liposarcoma; PLS: Pleomorphic liposarcoma; MPNST: Malignant peripheral nerve sheath tumour.