Table 4.
Univariable and multivariable Cox regression analyses for overall survival
| Factor |
Univariable analysis |
Multivariable analysis |
||
| HR (95%CI) | P value | HR (95%CI) | P value | |
| Age in yr | 1.00 (0.98-1.02) | 0.911 | - | - |
| Sex as female/male | 0.83 (0.45-1.53) | 0.559 | - | - |
| Tumor size in cm | 1.01 (0.96-1.05) | 0.722 | - | - |
| Number of tumors | ||||
| 1 | - | < 0.0011 | - | 0.0122 |
| ≥ 2 | 0.18 (0.08-0.41) | < 0.0011 | 0.27 (0.11-0.68) | 0.0052 |
| Infiltrative | 0.33 (0.15-0.71) | 0.0042 | 0.47 (0.21-1.05) | 0.067 |
| Portal vein invasion | ||||
| No invasion | - | 0.648 | - | - |
| Stage I-II | 0.83 (0.46-1.50) | 0.533 | - | - |
| Stage III-IV | 1.02 (0.58-1.78) | 0.946 | - | - |
| Extrahepatic metastasis | 1.37 (0.88-2.14) | 0.168 | - | - |
| Child-Pugh stage, A/B | 1.39 (0.74-2.62) | 0.305 | - | - |
| Performance status, 0/1 | 1.14 (0.74-1.76) | 0.560 | - | - |
| AFP in ng/mL | 1.00 (1.00-1.00) | 0.0162 | 1.00 (1.00-1.00) | 0.192 |
| Albumin in g/L | 0.97 (0.92-1.02) | 0.188 | - | - |
| Total bilirubin in mg/mL | 1.03 (1.00-1.05) | 0.0192 | 1.01 (0.98-1.03) | 0.505 |
| GGT | 1.00 (1.00-1.00) | < 0.0011 | 1.00 (1.00-1.00) | 0.060 |
| ALT | 1.00 (1.00-1.01) | 0.625 | - | - |
| AST | 1.00 (1.00-1.01) | 0.127 | - | - |
| Target treatment, yes/no | 0.65 (0.35-1.19) | 0.163 | - | - |
| S-1 treatment, yes/no | 1.00 (0.67-1.50) | 0.985 | - | - |
| Tumor response | ||||
| CR | - | < 0.0011 | - | < 0.0011 |
| PR | 0.02 (0.00-0.07) | < 0.0011 | 0.02 (0.00-0.09) | < 0.0011 |
| SD | 0.11 (0.06-0.21) | < 0.0011 | 0.11 (0.06-0.22) | < 0.0011 |
| PD | 0.20 (0.12-0.32) | < 0.0011 | 0.20 (0.12-0.32) | < 0.0011 |
1
The P value is < 0.001.
2
The P value is < 0.05. CI: Confidence interval; AFP: Alpha-fetoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; CR: Complete response; GGT: Gamma-glutamyl transferase; HR: Hazard ratio; PD: Progressive disease; PR: Partial response; SD: Stable disease.