Table 5.

Observed adverse events according to common terminology criteria for adverse events grading, n (%)

Adverse event	TACE/HAIC + S-1, n = 55	TACE/HAIC, n = 60	P value
Liver injury			0.243
Grades 1-2	28 (50.9)	23 (38.3)
Grades 3-4	27 (49.1)	37 (61.7)
Vomiting			0.478
Grades 1-2	23 (41.8)	29 (48.3)
Grades 3-4	1 (1.8)	0 (0)
Abdominal pain			0.820
Grades 1-2	37 (67.3)	37 (61.7)
Grades 3-4	10 (18.2)	13 (21.7)
Fever			0.277
Grades 1-2	45 (81.8)	44 (73.3)
Grades 3-4	0 (0)	0 (0)
Leukopenia			0.465
Grades 1	2 (3.6)	4 (6.7)
Grades 2-4	0 (0)	0 (0)
Thrombocytopenia			0.793
Grade 1	9 (16.4)	11 (18.3)
Grade 2	7 (12.7)	7 (11.7)
Grade 3	0 (0)	1 (1.7)
Grade 4	0 (0)	0 (0)
Anemia			0.220
Grade 1	7 (12.7)	15 (25.0)
Grade 2	2 (3.6)	5 (8.3)
Grade 3	1 (1.8)	1 (1.7)
Grade 4	0 (0)	0 (0)

HAIC: Hepatic arterial infusion chemotherapy; TACE: Transarterial chemoembolization.