Table 1.
Observed distribution of genotypes for ABCB1.
Abbreviated description of SNP combination group | Number of subjects | Combinations of variants | |
---|---|---|---|
Trial I | Trial II | ||
CGC/CGCa | 3 | 6 | 1236 C/C + 2677 G/G + 3435 C/C |
CGC/CGTa,b | 2 | 3 | 1236 C/C + 2677 G/G + 3435 C/T |
CGC/TTTa | 8 | 7 | 1236 C/T + 2677 G/T + 3435 C/T |
TTT/TTTa | 3 | 6 | 1236 T/T + 2677 T/T + 3435 T/T |
– | 1 | 1236 C/T + 2677 G/T + 3435 T/T | |
– | 1 | 1236 C/C + 2677 G/T + 3435 T/T |
a38 out of forty subjects in the two trials were included in our evaluation of the effect of SNP combinations. P-gp, P-glycoprotein.
bContains one non-compliant subject.