Table 2.

Model selection: Summary of covariate building steps for digoxin pharmacokinetics.

Model	Description	OFV	AIC
Base model
1	2-Compartment model with mixed-order absorption and linear elimination	− 1,166.40	− 1,072.41
Full model-selection of demographic and physiological covariates
2	Base model with separate estimates of bioavailability for different trials	− 1,238.98	− 1,142.98
3	Model 2 with additional separate estimates for first-order absorption rate constants of test period of trial II	− 1,284.96	− 1,183.58
Final mode with covariate
4	Final model with separate estimates of bioavailability according to CGC/CGC, CGC/CGT, CGC/TTT and TTT/TTT ABCB1 SNP combination groups	− 1,311.09	− 1,206.58

Summary of population pharmacokinetic model selection. Starting from the base model with a 2-compartment model, separate estimates for bioavailability and first-order absorption rate constants were introduced into the model. Finally, covariates on the bioavailability of different SNP combination were computed. OFV, objective function value; AIC, Akaike information criterion.