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. 2020 Jul 27;10:12508. doi: 10.1038/s41598-020-69422-z

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differences in plasma proteins between FM and CON using OPLS-DA modeling. (a) Score plot showing the separation between the FM and CON group. (b) Loading plot displaying proteoforms with VIP > 1. Numbers in the loading plot refers to equal spot numbers in (c), Table 2 and in supplementary Figure S1 and Table S1. (c) Heatmap showing individual (from each participant) optical density (OD) of quantified proteins for each proteoform with a VIP > 1 between FM and CON. The darker the color intensity, the higher OD of the proteoform (see color key). The loading and score plots were created in SIMCA P + (version 15), and the heatmap was created in R using the gplots package⁷⁴. +, upregulated in FM compared to CON; —, downregulated in FM compared to CON.