Table 2.
Significant plasma proteins in the OPLS-DA model of FM and CON.
| Spot number | Protein name | Accession number | VIPpred | p(corr) | Fold change FM versus CON |
|---|---|---|---|---|---|
| 9010 | Ig kappa chain C region | P01834 | 1.92 | − 0.56 | 0.40 |
| 7619 | Serotransferrin | P02787 | 1.61 | + 0.47 | 1.50 |
| 3403 | Alpha-2-antiplasmin | P08697 | 1.58 | + 0.46 | 2.04 |
| 8101 | Complement C4-B (fragment) | P0C0L5 | 1.57 | − 0.45 | 0.71 |
| 9106 | Fibrinogen alpha chain (fragment) | P02671 | 1.57 | − 0.45 | 0.27 |
| 4107 | Haptoglobin | P00738 | 1.51 | + 0.44 | 1.26 |
| 8413 | Fibrinogen alpha chain | P02671 | 1.49 | − 0.43 | 0.34 |
| 7621 | Serotransferrin | P02787 | 1.48 | + 0.43 | 1.17 |
| 7101 | Complement C4-B (fragment) | P0C0L5 | 1.48 | + 0.43 | 1.27 |
| 7203* | Fibrinogen beta chain | P02675 | 1.45 | + 0.42 | 1.59 |
| 3502 | Alpha-1B-glycoprotein | P04217 | 1.43 | − 0.41 | 0.87 |
| 9105 | Fibrinogen alpha chain (fragment) | P02671 | 1.37 | − 0.40 | 0.55 |
| 8706 | Plasminogen | P00747 | 1.37 | − 0.40 | 0.84 |
| 7403 | Complement C3 beta chain | P01024 | 1.33 | + 0.39 | 1.19 |
| 1404* | Kininogen-1 | P01042 | 1.33 | − 0.38 | 0.72 |
| 8701 | Plasminogen | P00747 | 1.30 | − 0.38 | 0.94 |
| 2410* | Alpha-2-antiplasmin | P08697 | 1.28 | − 0.37 | 0.66 |
| 4814 | Alpha-2-macroglobulin | P01023 | 1.28 | − 0.37 | 0.41 |
| 4401 | Alpha-2-antiplasmin | P08697 | 1.24 | − 0.36 | 0.84 |
| 9110 | Fibrinogen alpha chain (fragment) | P02671 | 1.24 | − 0.36 | 0.44 |
| 5602 | Complement C1r subcomponent | P00736 | 1.17 | − 0.34 | 0.85 |
| 4103 | Haptoglobin | P00738 | 1.14 | + 0.33 | 1.24 |
| 8703 | Plasminogen | P00747 | 1.12 | − 0.33 | 0.91 |
| 9701 | Plasminogen | P00747 | 1.11 | − 0.32 | 0.74 |
| 9007** | Ig kappa chain C region | P01834 | 1.11 | − 0.32 | 0.62 |
| 7206 | Beta-2-glycoprotein 1 | P02749 | 1.06 | + 0.31 | 1.10 |
| 8510 | Fibrinogen alpha chain | P02671 | 1.06 | + 0.31 | 1.19 |
| 9108 | Fibrinogen alpha chain (fragment) | P02671 | 1.05 | − 0.30 | 0.26 |
| 5903 | Alpha-2-macroglobulin | P01023 | 1.05 | − 0.30 | 0.65 |
| 2113 | Complement factor I light chain | P05156 | 1.05 | − 0.30 | 0.88 |
| 6606 | Gelsolin | P06396 | 1.03 | + 0.30 | 1.01 |
| 1004 | Apolipoprotein C-III | P02656 | 1.01 | − 0.29 | 0.33 |
| 6205 | Unidentified | Unknown | 1.01 | − 0.29 | 0.91 |
| 6726* | Complement C3b alpha chain | P01024 | 1.00 | − 0.29 | 0.73 |
| 3728 | Complement C1r subcomponent | P00736 | 1.00 | − 0.29 | 0.74 |
Spot numbers refers to equal numbers in Fig. 1b, c and marked proteins spots in supplementary Figure S1 and Table S1. Accession numbers are according to the protein data base UniProt (www.uniprot.org). Variable influence on projections (VIP) indicates the importance of the regressor, the higher value, the more important for the model. A VIP > 1 is considered as a significant protein, and here, only the significant proteins are shown. p(corr) is shown and is the multivariate correlation coefficient of each variable (protein) for the model. FM is coded 1, and CON coded 0. Hence, a positive p(corr) for a variable indicates a positive multivariate correlation versus FM belonging, and a negative p(corr), indicates a negative multivariate correlation with FM. For CON, the relationship is reversed. Please note that fold change is a univariate measure and do not necessarily correspond to p(corr); i.e., a positive fold change (FM > CON), is not automatically equal to a positive p(corr).
*Indicates shared proteoform in the model of PPT in FM, **indicated shared proteoform in the model of HADS in FM.