Table 5.
Plasma proteins associated with psychological distress in FM.
| Spot number | Protein name | Accession number | VIPpred | p(corr) | FM median OD (interquartile range) | CON median OD (interquartile range) | Fold change FM versus CON |
|---|---|---|---|---|---|---|---|
| Normal distress (HADS < 14) | |||||||
| 1207 | Alpha-2-HS-glycoprotein | P02765 | 2.02 | − 0.70 | 308 (847) | 579 (998) | 0.53 |
| 1205 | Alpha-2-HS-glycoprotein | P02765 | 1.96 | − 0.69 | 1,225 (1,883) | 1,041 (1,830) | 1.18 |
| 3301 | Vitamin D-binding protein | P02774 | 1.64 | − 0.57 | 2,511 (2,182) | 2,787 (2,446) | 0.90 |
| 1316 | Alpha-2-HS-glycoprotein | P02765 | 1.61 | − 0.56 | 153 (429) | 216 (274) | 0.71 |
| 2304 | Vitamin D-binding protein | P02774 | 1.52 | − 0.53 | 887 (705) | 1,247 (854) | 0.71 |
| 7205 | Fibrinogen beta chain | P02675 | 1.46 | − 0.51 | 777 (353) | 847 (278) | 0.92 |
| 2406 | Alpha-2-antiplasmin | P08697 | 1.44 | − 0.50 | 1,054 (763) | 1,114 (1,065) | 0.95 |
| 5405 | Hemopexin | P02790 | 1.33 | − 0.46 | 2,014 (680) | 1,868 (765) | 1.08 |
| 6507 | C4b-binding protein alpha chain | P04003 | 1.32 | − 0.46 | 381 (182) | 375 (277) | 1.02 |
| 9015 | Serum amyloid A-4 protein | P35542 | 1.31 | − 0.46 | 628 (869) | 487 (620) | 1.29 |
| 6104 | Ficolin-3 | O75636 | 1.24 | − 0.43 | 425 (196) | 449 (168) | 0.95 |
| 5706 | Complement C1r subcomponent | P00736 | 1.21 | − 0.42 | 99 (84) | 133 (118) | 0.74 |
| 1202 | Alpha-2-HS-glycoprotein | P02765 | 1.16 | − 0.41 | 1,373 (1,023) | 910 (1,409) | 1.51 |
| 6109 | Unidentified | Unknown | 1.08 | − 0.38 | 88 (94) | 71 (107) | 1.23 |
| 1310 | Kininogen-1 | P01042 | 1.05 | − 0.37 | 199 (130) | 226 (125) | 0.88 |
| 7311 | Unidentified | Unknown | 1.05 | − 0.37 | 203 (127) | 220 (116) | 0.92 |
| 7002 | Haptoglobin | P00738 | 1.02 | − 0.36 | 79 (210) | 72 (226) | 1.09 |
| Mild distress (HADS 15–20) | |||||||
| 3501 | Alpha-1B-glycoprotein | P04217 | 1.08 | + 0.38 | 2,822 (726) | 3,151 (576) | 0.90 |
| Moderate distress (HADS > 21) | |||||||
| 1203 | Alpha-2-HS-glycoprotein | P02765 | 1.51 | + 0.53 | 1,546 (1,218) | 1,702 (1,363) | 0.91 |
| 9406 | Fibrinogen alpha chain | P02671 | 1.36 | + 0.48 | 1,505 (1,762) | 1,844 (1,177) | 0.82 |
| 3010 | Apolipoprotein A-I | P02647 | 1.35 | + 0.47 | 64,643 (16,886) | 66,242 (17,870) | 0.98 |
| 9503 | Fibrinogen alpha chain | P02671 | 1.24 | + 0.43 | 2,844 (2,571) | 3,283 (2,001) | 0.87 |
| 9501 | Fibrinogen alpha chain | P02671 | 1.21 | + 0.42 | 3,688 (2,915) | 3,894 (2,478) | 0.95 |
| 9409 | Fibrinogen beta chain | P02675 | 1.12 | + 0.39 | 5,127 (2,617) | 5,497 (2,201) | 0.93 |
| 8509 | Fibrinogen alpha chain | P02671 | 1.11 | + 0.39 | 2,802 (2,207) | 2,736 (1,895) | 1.02 |
| 9007** | Ig kappa chain C region | P01834 | 1.01 | + 0.35 | 1,167 (1,888) | 1,883 (2,049) | 0.62 |
Proteins with a VIP > 1 associated with psychological distress in FM. Spot numbers refers to equal numbers in Fig. 7 and marked proteins spots in supplementary Figure S1 and Table S1. Accession numbers are according to the protein data base UniProt (www.uniprot.org). Variable influence on projections (VIP) indicates the importance of the regressor, the higher value, the more important for the model. A VIP > 1 is considered as a significant protein. p(corr) is shown and is the correlation coefficient of each variable (protein) for the model. A positive p(corr) for a variable indicates a positive multivariate correlation with the Y-variable (HADS total), and a negative p(corr), indicates a negative multivariate correlation with psychological distress in FM. The median quantified intensity (optical density, OD) from each group is shown in the table as a comparison. As descriptive values, protein fold change in FM compared to CON is reported. Please note that fold change is a univariate measure and do not necessarily correspond to p(corr); i.e. a positive fold change (FM > CON) is not automatically equal to a positive p(corr). The CON group is not included in the OPLS analysis.
**Indicates shared proteoform with the model of group differences in FM and CON.