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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Nat Cell Biol. 2019 Nov;21(11):1306–1308. doi: 10.1038/s41556-019-0405-3

Fig. 1 |. Translational variants of PTEN.

Fig. 1 |

PTEN mRNA (bottom) is translated into the canonical 403 amino acid (aa) PTEN protein or its longer translational variants PTENα and PTENβ depending on which translation initiation codon is used. PTENα and PTENβ contain an N-terminal extension unique to these isoforms that encodes a nuclear localization signal (NLS) and interaction domains for binding WDR5, FBXW11, and USP9X. FBXW11 and USP9X regulate ubiquitination and deubiquitination, respectively, of PTEN at lysines 235 and 239 (K235 and K239). “C-tail” represents the C-terminal tail domain of PTEN.