Table 5.
Genes containing exons skipped at different frequencies in aggressive vs. tame fox hypothalamic reads (FDR < 0.0001), including conserved domains overlapping the skipped exon.
| Gene | Exon Location | Percent Reads Skipping Exon (Tame) | Percent Reads Skipping Exon (Aggressive) | FDR | Skipped in Isoforms* | In Conserved Domains |
|---|---|---|---|---|---|---|
| GSTA4 | chr12: 20433452–20433585 | 0.253 | 1.773 | 0 | X1, X2, X3 | Thioredoxin_like super family |
| GSTA4 | chr12: 20435194–20435246 | 1.162 | 6.964 | 0 | X1, X2, X3 | None |
| GSTM4 | chr6: 42206292–42206393 | 0.391 | 4.652 | 0 | X1, X2, X3, X4 (Canis forms) | GST_C_family super family |
| GSTM4 | chr6: 42206493–42206575 | 0.562 | 5.977 | 0 | X1, X2, X3, X4 (Canis forms) | Thioredoxin_like super family |
| TMA16 | chr15: 59743149–59743234 | 0.204 | 5.519 | 4.92E-11 | X1, X2, X3 (Canis forms) | Tma16 super family |
| MTHFSD | chr5: 66312701–66312815 | 0.000 | 0.929 | 6.00E-11 | None | None |
| NA | Chr23: 27215997–27216139 | 4.983 | 0.715 | 5.33E-10 | X5, X6, X7 | None |
| CDKL2 | chr32: 168420–168527 | 3.841 | 14.218 | 5.62E-10 | X1, X2, X5 | None |
| DNAJC15 | chr22: 7795378–7795430 | 3.804 | 4.762 | 1.89E-08 | X1, X2 (Canis forms) | None |
| LRP12 | chr13: 5710069–5710126 | 14.973 | 28.571 | 2.53E-08 | X1 | None |
| MFAP5 | chr27: 37034668–37034704 | 8.654 | 0.921 | 4.55E-08 | X1 | None |
| MIOS | chr14: 23205051–23205181 | 4.888 | 4.211 | 8.67E-08 | X1, X2, X3 | RING_Ubox super family |
| UNC5D | chr16: 29308689–29308857 | 12.844 | 0.895 | 7.93E-08 | None | TSP1 |
| BCAS1 | chr24: 39703194–39703265 | 2.025 | 18.421 | 1.32E-07 | X1, X2, X3, X4, X5, X6 | None |
| FAM71E1 | chr1: 106261638–106261757 | 37.838 | 7.264 | 2.04E-07 | X1, X2 | None |
| DNAJC15 | chr22: 7792280–7792354 | 1.429 | 5.000 | 1.05E-06 | X1, X2 (Canis forms) | None |
| MPZL1 | chr7: 30684041–30684144 | 1.124 | 0.413 | 3.62E-06 | None | None |
| PTGDS | chr9: 48649471–48649611 | 0.724 | 10.638 | 7.45E-06 | None | Lipocalin |
| FBRSL1 | chr26: 542234–542303 | 2.769 | 2.542 | 8.98E-06 | X1, X2, X3, X4, X7, X8, X9, X12, X13, X15, X16, X17, X18, X19, X20, X21 | None |
| KIAA0556 | chr6: 19001226–19001494 | 5.252 | 10.294 | 1.70E-05 | X1, X2, X3 | None |
| TRIM65 | chr9: 4716736–4716911 | 19.811 | 4.594 | 2.92E-05 | X1, X2 | None |
| PECAM1 | chr9: 12181163–12181220 | 21.071 | 2.933 | 3.50E-05 | X1 | None |
| TADA2A | chr9: 37232686–37232758 | 7.849 | 2.616 | 3.96E-05 | X1, X2 | None |
| NA | chr17: 48250060–48250102 | 0.880 | 12.000 | 6.17E-05 | X1, X2, X3, X4, X5, X6, X7 | None |
| EPB41L5 | chr19: 29940406–29940471 | 27.778 | 3.826 | 0.000136 | X1, X2, X3, X4, X5 | None |
*
If not specified, the listed isoforms represent those in Vulpes vulpes.