Figure 8. Two-dimensional (2D) illustration of the small molecule interaction in the ACE2 binding site of the receptor-binding domain of SARS-CoV-2-S.
A) Interaction of streptomycin facilitated by five H-bonds, shown as pink arrows. B) Interaction of ciprofloxicine facilitated by two H-bonds, shown as pink arrows. C) Interaction of glycyrrhizic acid, facilitated by give H-bonds, shown as pink arrows. This figure was generated using Schrodinger’s Maestro visualizer. As an alternative, the open source visualizer Python Molecule Viewer (PMV) 48 could also be used.