Table 1.

Body weight and liver weight changes after exposure to PFOA in wild-type and Pparα-null mice

PFOA dose levels (umol/kg)	At the start of the experiment		At sacrifice after 4 wk dosing
	Gross body weight (g)	Body weight - Liver weight (g)a	Gross body weight (g)	Liver weight (g)	Relative liver weight (%)	Body weight - Liver weight (g)	Body weight gain excluded liver
Wild-type
0 (n=9)	23.9 ± 1.97	23.0 ± 1.89	26.6 ± 2.13	1.0 ± 0.08	3.7 ± 0.4	25.7 ± 2.22	2.7 ± 1.36
12.5 (n=10)	23.8 ± 0.79	22.9 ± 0.76	27.5 ± 2.07	3.2 ± 0.20***	11.3 ± 0.6***	24.7 ± 1.98	1.8 ± 1.95
25 (n=10)	24.2 ± 1.98	23.3 ± 1.90	25.5 ± 1.94	3.3 ± 0.30***	12.9 ± 0.8***	22.5 ± 1.71	−0.9 ± 1.64***
50 (n=10)	24.5 ± 1.67	23.6 ± 1.61	23.0 ± 2.90**	3.3 ± 0.45***	13.1 ± 0.9***	20.5 ± 2.50	−3.1 ± 2.09***
Pparα (−/−)
0 (n=10)	22.7 ± 1.53	21.6 ± 1.46	25.0 ± 1.56	1.0 ± 0.12	4.7 ± 2.1	24.1 ± 1.37	2.5 ± 0.58
12.5 (n=10)	23.2 ± 1.87	22.1 ± 1.78	27.9 ± 1.99**	3.3 ± 0.45***	11.6 ± 1.7***	25.1 ± 1.78	3.0 ± 1.44
25 (n=10)	23.5 ± 1.54	22.4 ± 1.47	27.4 ± 0.93*	3.4 ± 0.23***	11.9 ± 1.2***	24.5 ± 1.16	2.1 ± 1.37
50 (n=10)	23.4 ± 1.88	22.3 ± 1.80	26.4 ± 2.07	3.4 ± 0.51***	13.0 ± 1.6***	23.7 ± 2.64	1.4 ± 1.98

Note: Values are expressed as mean ± SD.

^*p<0.05,

^**p<0.01,

^***p<0.001 by Dunnett’s test compared with 0 μmol/kg.

^aLiver weight was assumed as 3.7% in wild-type and 4.7% in Pparα-null mice of gross body weight.