Table 2.

Plasma analysis of PFOA-treated wild-type and Pparα-null mice

PFOA dose levels (μmol/kg)	AST (IU/l)		ALT (IU/l)
	Wild-type	Pparα (−/−)	Wild-type	Pparα (−/−)
0 (n=9, 10)	145 ± 71.1	137 ± 25.9	26 ± 7.1	23 ± 7.2
12.5 (n=10)	175 ± 29.2	145 ± 31.5†	176 ± 62.4+++	136 ± 45.3+++
25 (n=10)	265 ± 146.2*	152 ± 20.2†	284 ± 158.9+++	176 ± 42.8+++
50 (n=10)	365 ± 106.0***	870 ± 523.5***††	328 ± 128.9+++	1356 ± 744+++†††
	T-Bil (mg/dl)		TBA (mmol/l)
	Wild-type	Pparα (−/−)	Wild-type	Pparα (−/−)
0 (n=9, 10)	0.09 ± 0.05	0.06 ± 0.02	4.5 ± 7.2	2.4 ± 2.6
12.5 (n=10)	0.05 ± 0.01*	0.02 ± 0.01†††	4.5 ± 1.6	1.0 ± 0†††
25 (n=10)	0.09 ± 0.03	0.03 ± 0.01†††	9.0 ± 4.6	1.4 ± 0.6††
50 (n=10)	0.15 ± 0.04**	0.47 ± 0.39***†	12.5 ± 9.9	34.8 ± 9.1***††
	T-Cho (mg/dl)		TG (mg/dl)
	Wild-type	Pparα (−/−)	Wild-type	Pparα (−/−)
0 (n=9, 10)	115 ± 9.7	136 ± 26.8†††	59 ± 17.6	45 ± 17.3
12.5 (n=10)	109 ± 17.7	84 ± 21.9***†	87 ± 15.7**	91 ± 35.5**
25 (n=10)	95 ± 15.4**	87 ± 13.7***	89 ± 28.4**	105 ± 23.8***
50 (n=10)	86 ± 11.6***	226 ± 23.0***†††	51 ± 18.4	114 ± 32.1***†††

AST, aspartate aminotransferase; ALT, alanine aminotransferase; T-Bil, total bilirubin.

TBA, total bile acid; T-Cho, total cholesterol; TG, triglyceride.

Data are expressed as mean ± SD.

^*p<0.05,

^**p<0.01,

^***p<0.001 by Dunnett’s test compared with 0 μmol/kg.

⁺p<0.05,

⁺⁺p<0.01,

⁺⁺⁺p<0.001 by Dunnett’s test after log-transformation due to heteroscedasticity (Levene’s test p<0.05).

^†p<0.05,

^††p<0.01,

^†††p<0.001 by t-test compared with wild-type and Pparα-null mice at same PFOA-dose level.