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. Author manuscript; available in PMC: 2020 Jul 28.
Published in final edited form as: Ind Health. 2010;48(1):96–107. doi: 10.2486/indhealth.48.96

Table 3.

Whole blood, bile and liver concentrations of PFOA in wild-type and Pparα-null mice

PFOA concentration (μg/ml)
PFOA dose levels (umol/kg) Whole blood Bile Liver
Wild-type Pparα (−/−) Wild-type Pparα (−/−) Wild-type Pparα (−/−)
0 (n=9, 10) nd nd nd nd nd nd
12.5 (n=10) 20.6 ± 2.4 19.3 ± 2.2 56.8 ± 26.9 19.6 ± 2.2 181.2 ± 6.3 172.3 ± 8.9
25 (n=10) 46.9 ± 3.2 36.4 ± 2.7* 784.0 ± 137.6 62.9 ± 16.7** 198.8 ± 15.4 218.3 ± 14.5
50 (n=10) 64.2 ± 6.5 71.2 ± 8.0 2174.0 ± 322.4 383.0 ± 109.9** 211.6 ± 13.3 239.7 ± 25.0

Data are expressed as mean ± SD.

*

p<0.05,

**

p<0.01,

***

p<0.001 by t-test compared between wild-type and Pparα-null mice.

nd; not detected (less than 0.001 μg/ml).