Skip to main content
. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Cancer Res. 2020 Apr 20;80(13):2833–2847. doi: 10.1158/0008-5472.CAN-19-2733

Figure 2.

Figure 2.

Oscillatory expression of ΔNp63 in a mouse model of mammary adenocarcinoma enhances metastatic dissemination. A, Experimental design to investigate effects of oscillatory expression of ΔNp63 in breast cancer metastasis using an inducible shRNA for ΔNp63 and an orthotopic model of metastatic mammary adenocarcinoma. B, Primary mammary tumor volume (mm3) of mice injected with DCIS-i-shΔNp63 cells and fed with different diet schedules of doxycycline (dox) as described in (A). Asterisk indicates p <0.05. NS is non-statistically significant using a two-tailed t test. C, Pie graphs indicating the percentage of mice with lung metastases among the experimental groups as described in (A). D, Working model demonstrating the effects of oscillatory expression of ΔNp63 in breast cancer metastasis.