Figure 2.

Inhibition of PI3K suppressed the PI3K/AKT/mTOR pathway in a COPD mouse model induced by PM2.5. Protein expression of PI3K, p-AKT, and p-mTOR by statistical analysis (a, b, and c) and western blotting assays of PI3K, p-AKT, and p-mTOR protein level (d). **P < 0.01 compared with sham group; ^##P < 0.01 compared with COPD model group. COPD, chronic obstructive pulmonary disease; PM2.5, particulate matter with a diameter <2.5 µm; PI3K, phosphatidylinositol 3-kinase; AKT, protein kinase B; mTOR, mammalian target of rapamycin; Sham, sham control mice group; Model, mouse model with COPD induced by PM2.5; PI3K inhibitor, treatment with PI3K inhibitor group.