Table 2.
The physiological role of major HDACs in the phenotype on vascular cells.
| Subtypes | Models | Functions and phenotypes | References |
|---|---|---|---|
| HDAC1 | ECs | Stimulates angiogenesis | Kim M S (12) |
| HAECs | Promote cell survival and prevent cell apoptosis | Li Y (81) | |
| HDAC2 | SMC | Inhibit cell proliferation | Findeisen HM (49) |
| HAECs | Inhibit vascular dysfunction | Pandey D 82) | |
| HDAC3 | ECs | Stimulate EC differentiation | Zang L (17) |
| Macrophages | Upregulate in atherosclerosis | Hoeksema MA (85) | |
| HDAC5 | ECs | Repress angiogenesis | Urbich CL (22) |
| HUVECs | Repress angiogenesis | Ha CH (21) | |
| HDAC6 | Mice | Increase blood pressure and vasoconstriction | Chi Z (25) |
| SHR | Increase vascular hyperplasia or vasoconstriction | Choi SY (62) | |
| ApoE-/- mice | Develop atherosclerosis | Leucker TM (90) | |
| HDAC7 | ECs | Stimulate cell migration | Mottet D(27) |
| Mouse | Rupture of blood vessels | Chang S (28) | |
| HDAC8 | SMCs | The marker of smooth muscle differentiation | Waltregny D (54) |
| HDAC9 | Rats | Increase EC permeability | Shi W (38) |
| LDLr-/- mice | Develop atherosclerosis | Cao Q (94) | |
| HDAC10 | ECs | Stimulate tube formation | Duan B (39) |
| HDAC11 | Rats | Induce vessel injury | Zhou B (40) |
| SIRT1 | EC | Modulate homeostasis | Wan, Z (44) |
| Mice | Inhibit vascular remodeling | Gao P (70) | |
| Mice | Inhibit neointima formation | Li L (71) | |
| HUVECs | Enhance EC survival | Zhang QJ (87) | |
| ECs | Anti-inflammation | Stein S (88) | |
| SIRT3 | SMCs | Decrease proliferation | Wu X (72) |
| SIRT6 | ECs | Prevent senescence | Cardus A (48) |
HAECs: human aortic endothelial cells; HUVECs: human umbilical vein endothelial cells. SHR: spontaneously hypertensive rat. ECs: endothelial cells: SMCs: smooth muscle cells.