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. Author manuscript; available in PMC: 2020 Jul 28.
Published in final edited form as: Nat Med. 2019 Oct 7;25(10):1607–1614. doi: 10.1038/s41591-019-0584-2

Extended Data Fig. 5 |. Comparison of nuclear mismatch repair proteins between patient and tumoroid samples.

Extended Data Fig. 5 |

Immunohistochemistry of the nuclear mismatch repair (MMR) proteins MSH2, MSH6, MLH1, and PMS2. The presence of each protein is assessed by nuclear staining verified by pathologic analysis with (+) indicating present and (−) indicating absent staining. a, Displayed are two MMR-proficient tumoroids, RC-MSK-001 and RC-MSK-002. b, Displayed are two MMR-deficient tumors. RC-MSK-031 is deficient in MSH2 and MSH6. RC-MSK-034 is deficient in MLH1 and PMS2. Scale bars, 50 μm. All representative images are from one patient-specific tumor-to-tumoroid derivation.