A 73-year-old woman with unresectable pancreatic adenocarcinoma with encasement and occlusion of the portal vein/SMV confluence, treated with FOLFIRINOX. Tumor diameter decreased to 85% of the baseline, tumor volume 59%, and CA19–9 47% after chemotherapy. A Baseline arterial and B venous phase CT. C Post-chemotherapy arterial and D venous phase CT. Tumor iodine uptake and normalized tumor iodine uptake were A 1.0 mg/mL and 6%, B 1.6 mg/mL and 45%, C 0.4 mg/mL and 3%, and D 1.3 mg/mL and 21%.