A 47-year-old man with pancreatic adenocarcinoma arising from the pancreatic neck with encasement of the celiac axis and common hepatic artery, treated with FOLFIRINOX. Tumor diameter decreased to 75% of the baseline, tumor volume 57%, and CA19–9 70%. A Baseline arterial and B venous phase CT. C Post-chemotherapy arterial and D venous phase CT. Tumor iodine uptake and normalized tumor iodine uptake were A 1.5 mg/mL and 23%, B 1.7 mg/mL and 43%, C 1.4 mg/mL and 13%, and D 1.6 mg/mL and 38%. After completion of chemotherapy, patient had radiation therapy followed by pancreaticoduodenectomy. Pathology revealed 0.5 cm poorly differentiated adenocarcinoma in the pancreas and an area of dense scarring associated with large blood vessels, ganglia, and nerve trunks without remaining tumor.