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. Author manuscript; available in PMC: 2020 Jul 28.
Published in final edited form as: Anticancer Agents Med Chem. 2011 May 1;11(4):347–358. doi: 10.2174/187152011795677526

Table 2.

Oxygen Dependence of the Rate Constant of Tempol Reduction in Various Cell Types

Cell Type knitrogen/kair p(knitrogen=kair) Reference
Mouse thymus-bone marrow cells l;0.96 n.s.* [11,71]
Rat hepatocytes 1.2 n.s. [112]
Adriamycin-resistant MCF7 1.2 n.s. [53]
Human skin fibroblast (1522) 1.7 p<0.05 [53]
Squamous cell carcinoma VII 1.8 p<0.05 [12]
Human breast cancer (MCF7) 2.0 p<0.05 [53]
Radiation-induced fibrosarcoma (RIF-1) 2.6 p<0.05 [53]
*

n.s.: not significant. For each of these experiments, the reduction rate of Tempol was measured under ambient gas and under anoxic gas conditions. The ratio of these two values is given in the “kNitrogen/kair” column. A kNitrogen/kair = 1 suggests that the reduction rate of Tempol is not oxygen dependent in those cells.