Table 2.
Summary of viruses inhibited and augmented by hypoxia
| Mechanism | Cell Line | Conditions | Reference | |
|---|---|---|---|---|
| Inhibited | ||||
| Adenovirus | Cell arrest | H1299 / A549 | 1% oxygen | [119, 132] |
| SV40 | Blocks replication | CV1 | 0.02% oxygen | [124] |
| H1 parvovirus | ND | Constitutive expression of HIF1α | [25] | |
| VSV | Increase in innate immune responses | RCC | Constitutive expression of HIF1α | [69] |
| Augmented | ||||
| DENV | Increased antibody dependent uptake via upregulation of FcγRIIA and membrane ether lipid concentrations | THP-1, Primary Monocytes | 3% oxygen | [46] |
| Correlated with increased anaerobic glycolysis for increased ATP production | Huh7 | 3% oxygen | [42] | |
| EBV | Induce reactivation of EBV | Burkitt lymphoma Sal | Deferoxamine (DFX) | [90] |
| HSV | Hypoxia induced GADD34 | U87 | 5% oxygen | [2] |
| HCV | ATP increase due to the induction of anaerobic glycolysis | Huh7.5 | 3% oxygen | [139] |
| Sendai Virus | ND | Rhabdomyosarcoma | 3 Kpa | [37] |
| KSHV | HIF1α induction of viral Rta promoter | Hep3B | Expression of reporter plasmids containing Rta promoter | [58] |
ND Not determined