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. 2020 Jul 27;17:115. doi: 10.1186/s12985-020-01374-2

Table 3.

Viruses that induces a pseudohypoxic state

Induces Hypoxia Response Effect Mechanism Cell Line Reference
Influenza HIF1α stabalization Impaired proteasome function results in decreased degradation of HIF1α A549 [123]
Hepatitis B Virus (HBV) HIF1α stabalization HBx inhibits binding of VHL to HIF2α HepG2, L02 [68]
HIF1α stabalization HBx activates MAPK pathway which in turns induces the activity of HIF1α Chang X-34, HepG2 [153]
VACV HIF1α stabalization C16 inhibition of PHD2 Hek293T [100]
EBV Increased protein synthesis of HIF1α LMP induced KR-4 [141]