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. 2020 Jul 27;17:115. doi: 10.1186/s12985-020-01374-2

Table 4.

Summary of HIF1α inhibitors

Mode of inhibition Compound Target Reference
HIF1α mRNA EZN-2968 HIF1α [117]
HIF1α Translation Topotecan / AZN-2208 Topoisomerase 1 [6, 127]
PX-478 HIF1 / HIF2 Protein [88]
Digoxin HIF1α protein [156]
Temisirolimus / Everolimus / MLN0128 / Metformin mTOR [73, 157]
Wortmannin PI3K [155]
HIF1α Degradation 17-AAG / 17-DMAG HSP90 [110]
Romidepsin / Trichostatin HDAC [71, 81]
LW6 HDAC / VHL [85]
HIF1α DNA Binding DJ12 HRE [79]
HIF1α transcriptional activity Chetomin CH1 domain pf p300 [83]