Table 4.
Associations analyses between VEGFA-rs3025039 and AMS
| Model | Allele/Genotype | AMS group (n = 320) | Non-AMS group (n = 284) | OR (95% CI) | P-value | OR (95% CI)a | P-valuea | Q-value |
|---|---|---|---|---|---|---|---|---|
| Allele | C | 523 (82.2) | 497 (87.5) | – | 0.011* | – | – | – |
| T | 113 (17.8) | 71 (12.5) | – | – | ||||
| Codominant | CC | 214 (67.3) | 215 (75.7) | 1 | 0.021* | 1 | 0.022* | 0.253 |
| CT | 95 (29.9) | 67 (23.6) | 1.42 (0.99–2.05) | 1.42 (0.98–2.05) | ||||
| TT | 9 (2.8) | 2 (0.7) | 4.52 (0.97–21.17) | 4.56 (0.97–21.49) | ||||
| Dominant | CC | 214 (67.3) | 215 (75.7) | 1 | 0.022* | 1 | 0.024* | 0.184 |
| CT/TT | 104 (32.7) | 69 (24.3) | 1.51 (1.06–2.17) | 1.51 (1.05–2.16) | ||||
| Recessive | CT/CC | 309 (97.2) | 282 (99.3) | 1 | 0.042 | 1 | 0.042 | 0.483 |
| TT | 9 (2.8) | 2 (0.7) | 4.11 (0.88–19.16) | 4.15 (0.88–19.48) |
a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval