Table 5.
Associations analyses between PPARA-rs7292407 and AMS
| Model | Allele/Genotype | AMS group (n = 320) | Non-AMS group (n = 284) | OR (95% CI) | P-value | OR (95% CI)a | P-valuea | Q-value |
|---|---|---|---|---|---|---|---|---|
| Allele | C | 524 (87.3) | 445 (82.1) | – | 0.014* | – | – | – |
| A | 76 (12.7) | 97 (17.9) | – | – | ||||
| Codominant | CC | 230 (76.7) | 187 (69.0) | 1 | 0.050 | 1 | 0.068 | 0.313 |
| AC | 64 (21.3) | 71 (26.2) | 0.73 (0.50–1.08) | 0.73 (0.50–1.09) | ||||
| AA | 6 (2.0) | 13 (4.8) | 0.38 (0.14–1.01) | 0.40 (0.15–1.07) | ||||
| Dominant | CC | 230 (76.7) | 187 (69.0) | 1 | 0.039* | 1 | 0.046* | 0.265 |
| AC/AA | 70 (23.3) | 84 (31.0) | 0.68 (0.47–0.98) | 0.68 (0.47–0.99) | ||||
| Recessive | CC/AC | 294 (98.0) | 258 (95.2) | 1 | 0.061 | 1 | 0.083 | 0.318 |
| AA | 6 (2.0) | 13 (4.8) | 0.41 (0.15–1.08) | 0.43 (0.16–1.16) |
a adjusted for age, BMI and smoking status. * P < 0.05 indicted significant difference. “-” indicated “not available” for regression analysis or multiple hypothesis testing correction. Q-value was calculated using Benjamini and Hochberg method in multiple hypothesis testing including 23 SNPs for AMS association analysis. SNP Single nucleotide polymorphism; AMS Acute mountain sickness; BMI Body mass index; OR Odds ratio; CI Confidence interval