. 2020 Jul 20;40(7):995–1000. [Article in Chinese] doi: 10.12122/j.issn.1673-4254.2020.07.12

4.

3, 29-DK在大鼠体内的药代动力学参数比较

Comparison of pharmacokinetic parameters of 3, 29-DK in rats (Mean±SD, n=6)

Parameters	Trichosanthes extract group	Trichosanthes sustained-release pellets group
^P < 0.05, ^*P < 0.01 vs trichosanthes extract group.
AUC_(0-t)/(μg/L·h)	15.67±2.25	172.12±8.12^**
AUC_(0-∞)/(μg/L·h)	16.04±2.16	190.06±14.54^*
MRT_(0-t)/h	1.31±0.078	15.51±0.40^*
MRT_(0-∞)/h	1.43±0.17	20.74±1.32^*
t_1/2z/h	0.91±0.30	12.21±2.37^**
T_max/h	0.63±0.14	7.67±0.82^**
C_max/(ng/mL)	14.8±2.81	9.96±0.69^*
V_z/F/(L/kg)	0.067±0.026	1374.56±3670.62^*
CL_z/F/(L/h/kg)	0.051±0.0070	1374.56±10³.59^*