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. 2020 Jul 28;128(3):383–392. doi: 10.1016/j.ophtha.2020.07.045

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© 2020 by the American Academy of Ophthalmology.

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Illustrative examples of eyes included in the study that showed progression detected by spectral-domain (SD) OCT retinal nerve fiber layer (RNFL) thickness during follow-up. The sequence of fundus photographs shows 6 photographs, including the baseline (leftmost) and last (rightmost) available photographs during follow-up and randomly chosen intermediate ones. Slopes of change are shown adjacent to the sequence of photographs, colored in blue for the SD OCT slope and in red for the slope of predicted RNFL thickness from fundus photographs. A, B, C, Excellent agreement between SD OCT and predicted RNFL from photographs, with clear changes also seen by inspection of the fundus photographs. Of note, disc hemorrhages can be seen during follow-up in (A) and (C). D, Small, albeit statistically significant, changes on SD OCT, but the slope for predicted RNFL thickness from photographs remained relatively flat. M2M = machine-to-machine.