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. 2020 Jul 28;128(3):383–392. doi: 10.1016/j.ophtha.2020.07.045

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© 2020 by the American Academy of Ophthalmology.

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Illustrative examples of eyes included in the study that were considered nonprogressors according to spectral-domain (SD) OCT retinal nerve fiber layer (RNFL) thickness during follow-up. The sequence of fundus photographs shows 6 photographs, including the baseline (leftmost) and last (rightmost) available photographs during follow-up and randomly chosen intermediate ones. Slopes of change are shown adjacent to the sequence of photographs, colored in blue for the SD OCT slope and in red for the slope of predicted RNFL thickness from fundus photographs. A, B, Good agreement in the slopes. C, Eye with advanced glaucoma that showed large variation on SD OCT RNFL thickness measurements, close to the floor. Predicted fundus photograph RNFL thickness remained stable over time. D, Mild decline of predicted RNFL thickness over time, whereas SD OCT remained essentially stable. Interestingly, this eye showed an inferior temporal disc hemorrhage over time, and also, changes in the inferior blood vessel seem to suggest an increase in the inferior cupping and rim loss. M2M = machine to machine.