Associations between preceding skin thickness progression rate and skin immune cell type signatures in PRESS SSc patients. Skin thickness progression rate (mRSS at the time of biopsy/years since first skin thickening or puffy fingers) preceding the skin biopsy is plotted on the x-axis. Cell type signature scores for (A) M1 macrophages, (B) M2 macrophages, (C) CD4 cells, (D) CD8 T cells or (E) B cells are plotted on the y-axis. mRSS, modified Rodnan Skin Score; PRESS, Prospective Registry for Early Systemic Sclerosis; SSc, systemic sclerosis; ST, skin thickness.