Table 3.

Correlation of immune cell gene expression signatures with immunohistochemical staining of immune cell markers

Cell abundance by IHC staining	Cell type signature score	Spearman’s r (p value)
CD68	M1 macrophage	0.45 (0.02)
CD68	M2 macrophage	0.50 (0.01)
CD163	M1 macrophage	0.47 (0.02)
CD163	M2 macrophage	0.57 (<0.01)
AIF1	M1 macrophage	0.66 (<0.01)
AIF1	M2 macrophage	0.69 (<0.01)
CD3	CD4 T cell	0.61 (<0.01)
CD3	CD8 T cell	0.63 (<0.01)
CD4	CD4 T cell	0.49 (<0.01)
CD8	CD8 T cell	0.67 (<0.01)
CD20	B cell	0.54 (<0.01)
CD56	NK cell	0.24 (0.22)

IHC, immunohistochemical; NK, natural killer.