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. 2020 Jul 21;11(7):e00213. doi: 10.14309/ctg.0000000000000213

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© 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work, provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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Figure 3. — Weighted genetic risk scores (wGRS) in patients with familial IBD. A rank-based nonparametric approach was used to estimate the levels of significance for the increase in disease-specific GRS for (a) IBD, (b) CD, and (c) UC in patients in each family based on the rank of observed wGRS within the simulated wGRS distribution of a general population (n = 100,000; indicated by gray histograms). At a false-discovery rate of 5%, a statistical significance for the wGRS inflation was determined at a nominal P value of 6.25 × 10⁻³ in IBD, 1.25 × 10⁻² in CD, and 2.5 × 10⁻² in UC, meaning that wGRS values over 4.06 in IBD, 3.94 in CD, and 4.33 in UC are, respectively, considered significantly higher than expected. Patients in a single CD family (indicated by *) had a significantly high wGRS. CD, Crohn disease; IBD, inflammatory bowel disease; UC, ulcerative colitis.