Table 2.
Features and outcomes of the patients stratified by normal/low antithrombin levels.
| variable | Total patients (n = 49) | Patients with normal AT (n = 34) | Patients with low AT (n = 15) | p-value |
|---|---|---|---|---|
| Age (years) | 69.4 ± 14.8 | 71.0 ± 13.8 | 65.7 ± 16.9 | 0.2507 |
| Males (%) | 49.0 | 47.1 | 53.3 | 0.7624 |
| History of Diabetes (%) | 20.4 | 23.5 | 13.3 | 0.7021 |
| History of Hypertension (%) | 34.7 | 35.3 | 33.3 | 0.9999 |
| History of CVD (%) | 16.3 | 17.6 | 13.3 | 0.9898 |
| History of Lung Disease (%) | 16.3 | 17.6 | 13.3 | 0.9898 |
| BMI | 29.1 ± 7.0 | 27.5 ± 5.9 | 32.9 ± 7.9 | 0.0104 |
| eGFR (ml/min) | 70.6 ± 27.0 | 68.1 ± 28.8 | 76.1 ± 22.2 | 0.3448 |
| CRP (mg/L) | 122.5 ± 85.5 | 121.7 ± 83.8 | 124.4 ± 92.3 | 0.8530 |
| D-dimer (ng/ml) | 1848.7 ± 5949.4 | 2455.5 ± 7084.2 | 433.3 ± 375.2 | 0.7065 |
| High-sensitivity Troponin (pg/ml) | 20.1 ± 25.2 | 18.4 ± 25.1 | 23.8 ± 25.9 | 0.1789 |
| AT (%) | 87.2 ± 23.2 | 99.6 ± 15.2 | 59.2 ± 9.4 | <0.0001 |
| Prothrombin time (sec) | 13.1 ± 3.1 | 12.9 ± 2.3 | 13.6 ± 4.4 | 0.4948 |
| activated partial-thromboplastin time (sec) | 32.6 ± 5.4 | 33.3 ± 5.6 | 31.1 ± 5.0 | 0.2050 |
| SaO2 (%) | 90.5 ± 5.8 | 91.8 ± 5.2 | 89.1 ± 7.0 | 0.1342 |
| Lactate dehydrogenase (U/L) | 344.7 ± 161.4 | 333.7 ± 159.0 | 369.7 ± 169.6 | 0.3794 |
| Non-survivors (%) | 32.6 | 17.6 | 66.7 | 0.0019 |
| Survivors who required mechanical ventilation (%) | 24.3 | 14.3 | 80 | 0.0076 |
| Non survivors and survivors who required mechanical ventilation (%) | 49.0 | 29.4 | 93.3 | <0.0001 |
AT: antithrombin; SaO2: oxygen saturation; BMI: body mass index. CVD: cardiovascular Disease; CRP: C-reactive Protein.