Table 2:

Reasons for transplant ineligibility and non-transplant

Reasons for BMT Ineligibility at MDS diagnosis	N (%)
Total	68 (18.8)
Metastatic Cancer within 5 years of MDS diagnosis	37 (54.4)
ECOG >2	9 (13.2)
DLCO adjusted for Hemoglobin <50% or FEV1<1.5L	7 (10.3)
Left ventricular ejection fraction <40%	6 (8.8)
Creatinine >/=2mg/dL	5 (7.4)
Documented liver cirrhosis	4 (5.9)
Uncontrolled infection	0
Reason for non transplant among 135 patients who were eligible and who had a transplant indication.
Total	135
Died*	60 (44.4)
Lost to follow-up	32 (23.7)
Progressive MDS at last review	20 (14.8)
New co-morbidity, still alive**	10 (7.4)
Refused	6 (4.4)
No suitable donor	4 (3.0)
Not referred for HCT	2 (1.5)
Lack social support	1 (0.7)

DLCO: Oxygen diffusion capacity, FEV1: forced expiratory volume in 1 second.

^*Cause of death was attributed to MDS in 56/60 (93%) patients who died and was unknown in 4/60 (7%).

^**Development of a new co-morbidity in those alive at last follow-up was the primary reason for non-transplant in 10 (7.4%) patients. These new co-morbidities included organ failure (n=3), other active neoplasm (n=3), uncontrolled infection (n=2), patient reaching age >75yr (n=1) and development of other co-morbidity (n=1).