Study	Reason for exclusion
De Cruz 2015	Study compared 2 different treatment protocols for CD patients following intestinal resection. Participants in both groups received adalimumab
Dewint 2014	All participants received adalimumab, Study compared combination of adalimumab and ciprofloxacin to adalimumab. Overall comparison discusses whether antibiotic is superior to placebo for perianal fistula closure
Faubion 2017	This was an open‐label extension study with no control group
Khanna 2015	Cluster‐randomized controlled trial of 2 different treatment algorithms for treatment of CD. Both treatment algorithms involved the use of adalimumab