Figure 3.
Interactions of the nsp13-ZBDs with the RTC
(A and B) Views of the nsp13-ZBD:RTC interactions. Proteins are shown as α-carbon backbone worms. Side chains that make protein:protein interactions are shown. Polar interactions are shown as dashed gray lines. Sequence logos (Schneider and Stephens, 1990) from alignments of α- and β-CoV clades for the interacting regions are shown. The residues involved in protein:protein interactions are labeled under the logos. Dots above the logos denote conserved interacting residues.
(A) View of the tripartite nsp13.1-ZBD:nsp8b extension:nsp12 thumb interaction. The adventitiously bound CHAPSO molecule is shown in dark gray.
(B) View of the nsp13.2-ZBD:nsp8a extension interaction.