Table 4.

Examples Of Anti CoV Therapeutic Strategies (Adapted43, 55, 56, 57).

Mode of action	Drug
Virus entry blockers	Anti-S protein monoclonal antibodies Peptides that bind to the heptad repeat on the S (spike) protein Peptides that bind to other regions of S and block oligomerisation, etc.
Virus replication blockers	3C-like protease inhibitors Other viral protease inhibitors, e.g. papain-like cysteine protease nsp1–16 Viral polymerase inhibitors Nelfinavir, lopinavir/ritonavir, ribavirin, RNAi, glycyrrhizin, niclosamide
Immune modulators	Type 1 interferons Lopinavir/ritonavir