Table 2.
Epidemiological, clinical, and pathological characteristics according to the histological classification of mixed tumors in bitches.
| Variables | Benign mixed tumor | Carcinomasin mixed tumors | Carcinosarcoma | P value |
|---|---|---|---|---|
| Number of cases | 162 (18%) | 682 (75%) | 60 (7%) | |
| Time of development (days) | 297.25 ± 420.13 | 367.8 ± 430.98 | 570.5 ± 599.47 | 0.034 |
| Age | 8.89 ± 2.69 | 9.68 ± 2.74 | 10.50 ± 2.76 | <0.001 |
| Breed | ||||
| Pure | 131 (84%) | 502 (78.2%) | 41 (70.7%) | 0.860 |
| Mixed | 25 (16%) | 140 (21.8%) | 17 (29.3%) | |
| Ovariohysterectomy | ||||
| Yes | 16 (26.2%) | 87 (20.5%) | 11 (26.2%) | 0.453 |
| No | 45 (73.8%) | 337 (79.5%) | 31 (73.8%) | |
| Pseudocyesis | ||||
| Present | 27 (55.1%) | 124 (39.6%) | 9 (32.1%) | 0.075 |
| Absent | 22 (44.9%) | 189 (60.4%) | 19 (67.9%) | |
| Estrous cycle | ||||
| Regular | 33 (71.7%) | 243 (73.4%) | 22 (68.8%) | 0.838 |
| Irregular | 13 (28.3%) | 88 (26.6%) | 10 (31.3%) | |
| Hormone administration | ||||
| Yes | 3 (6.8%) | 23 (7.4%) | 3 (9.4%) | 0.907 |
| No | 41 (93.2%) | 287 (92.6%) | 29(90.6%) | |
| Location | ||||
| Cranial thoracic | 7 (5.1%) | 35 (6.0%) | 4 (7.8%) | 0.251 |
| Caudal thoracic | 20 (14.5%) | 84 (14.5%) | 1 (2.0%) | |
| Cranial abdominal | 15 (10.9%) | 110 (19%) | 11 (21.6%) | |
| Caudal abdominal | 44 (31.9%) | 161 (27.8%) | 15 (29.4%) | |
| Inguinal | 52 (37.7%) | 189 (32.6%) | 20 (39.2%) | |
| Adherence | ||||
| Absent | 160 (98.8) | 616 (91.4%) | 47 (78.3%) | <0.001 |
| Present | 2 (1.2%) | 58 (8.6%) | 13 (21.7%) | |
| Ulceration | ||||
| Absent | 161 (99.4%) | 646 (95.8%) | 52 (86.7%) | <0.001 |
| Present | 1 (0.6%) | 28 (4.2%) | 8 (13.3%) | |
| Relapse and/or distant metastases | ||||
| Absent | 162 (100%) | 646(95.8%) | 44 (71.1%) | <0.001 |
| Present | 0 | 28 (4.2%) | 16(27.8%) | |
| Size | ||||
| T1 < 3.0 cm | 97 (76.4%) | 328 (56.3%) | 5 (10.4%) | <0.001 |
| T2 3.0–5.0 cm | 18 (14.2%) | 142 (24.4%) | 11 (22.9%) | |
| T3 > 5.0 cm | 12 (9.4%) | 113 (19.4%) | 32 (66.7%) | |
| Clinical stage | ||||
| I | 97 (76.4%) | 318 (54.5%) | 3 (6%) | <0.001 |
| II | 18 (14.2%) | 132 (22.6%) | 8 (16%) | |
| III | 12 (9.4%) | 90 (15.4%) | 24 (48%) | |
| IV | - | 42 (7.2%) | 13 (26%) | |
| V | - | 2 (0.3%) | 2 (4%) | |
| Histological grade | ||||
| I | 59 (67%) | 3 (17.7%) | <0.001 | |
| II | 26 (29.6%) | 6 (35.3%) | ||
| III | 3 (3.4%) | 8 (47.1%) | ||