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. 2015 May 8;2015(5):CD007017. doi: 10.1002/14651858.CD007017.pub2

Summary of findings 3. Fixed co‐payment.

Patient or population: seniors and general population
Settings: high‐income countries (US, CN, Sweden)
Intervention: implementation of or increase in fixed co‐payment
Comparison: lower value of fixed co‐payment or full medicines coverage
Outcomes Impact Number of 
 studies Certainty of the evidence 
 (GRADE) Plain language summary Comments
Medicine use
Overall use of medicines Small decrease 2 (ITS1) ⊕⊖⊖⊖ Very low5 Effect of intervention on overall use of medicines is uncertain.
However, it may decrease use of medicines for symptomatic and asymptomatic conditions
Use of all medicines in these studies decreased after implementation of/increase in co‐payment, with the exception of oral hypoglycaemics, for which the increase in co‐payment was low
Use of medicines for symptomatic conditions Small decrease 3 (ITS2) ⊕⊕⊖⊖ Low
Use of medicines for asymptomatic conditions Small decrease 3 (ITS3) ⊕⊕⊖⊖ Low
Cost
Patient perspective No studies 0 Intervention may slightly decrease insurer expenditures on medicines. Effect on patient expenditures and insurer expenditures on health care was not reported Magnitude of decrease in insurer expenditures on medicine was variable, ranging from ‐16.9% to 0.1%
Insurer perspective (expenditures on medicines) Small decrease 3 (ITS 4) ⊕⊕⊖⊖ Low
Insurer perspective (expenditures on health care) No studies 0
Healthcare utilisation
Overall healthcare utilisation No studies 0 No studies were found that reported effects of this intervention on healthcare utilisation
Emergency department and hospitalisation No studies 0
Outpatient care No studies 0
Health outcome No studies 0 No studies were found that reported effects of this intervention on health outcomes
GRADE Working Group grades of evidence.
 High certainty: This research provides a very good indication of the likely effect. The likelihood that the effect will be substantially different is low.
Moderate certainty: This research provides a good indication of the likely effect. The likelihood that the effect will be substantially different is moderate.
 Low certainty: This research provides some indication of the likely effect. However, the likelihood that it will be substantially different is high.
 Very low certainty: This research does not provide a reliable indication of the likely effect. The likelihood that the effect will be substantially different is very high.

Substantially different = a large enough difference that it might affect a decision.

1. Nelson 1984; Hux 1997.

2. Hux 1997; Ong 2003; Reeder 1985

3. Reeder 1985; Hux 1997; Roblin 2005

4. Sawyer 1982; Nelson 1984; Hux 1997.

5. Downgraded because of risk of bias.