. Author manuscript; available in PMC: 2021 Apr 23.

Published in final edited form as: J Med Chem. 2020 Mar 27;63(8):3896–3907. doi: 10.1021/acs.jmedchem.9b01501

Table 1.

Anti-HCMV activity of the five compounds against different strains of HCMV, toxicity and slope.

Compound	EC₅₀ - Towne (μM)	EC₅₀ - GCVR Towne (μM)	EC₅₀ - TB40 [μM]	CC₅₀ (μM)	Slope
MLS8969	0.55±0.1^*	0.25±0.1^*	0.12±0.0^*	>500	0.64±0.1^*
NFU1827	0.85±0.1	0.84±0.1	1.21±0.1	70.9	1.27±0.1
MLS8554	0.64±0.1	0.17+0.0	0.34±0.0	86.0	1.02±0.1
MLS8091	0.39±0.0	0.26±0.0	0.33±0.0	>250	1.37±0.3
NCGC2955	4.61±1.4	1.4±0.2^**	1.18±0.2	>200	0.80±0.1
GCV	2.1±0.3	29.7±1.2	0.72±0.0	>200	0.93±0.1

= pre treatment followed by plaque reduction assay

^**

= plaque reduction assay