Table 1.

Probabilities of Major Events per Monthly Cycle—BTT and DT

Event	BTT	DT	Reference
Stroke
Ischemic	0.007	0.014	†‡
Hemorrhagic	0.007	0.005	†‡
Pump exchange
VAD thrombus	0.003	0.005	†‡
VAD failure	0.002	0.001	†‡
Driveline Infection	0.021	0.020	†‡
GI bleed	0.023	0.048	†‡
RHF	0.031	0.023	†‡
RVAD	11%	7%	†‡
Other AEs	0.043	0.380	†‡
MM stroke	0.002	0.002	12
MM readmission (apart from stroke)	0.300	0.300	12
Heart transplant rate	2.83%	—	22

The values presented at the table are transformed monthly event rates as used in the model.

*Based on ENDURANCE Supplemental¹⁹ Data. Medtronic Internal Data on File.

†Based on ADVANCE BTT + CAP^17,18,40 Data. Medtronic Internal Data on File.

BTT, bridge-to-transplant; DT, destination therapy; VAD, ventricular assist device; GI, Gastrointestinal; RHF, right heart failure; RVAD, right ventricular assist device; AE, adverse event; MM, medical management