(A) Kaplan-Meier plot of the survival of female mice in which cancer was observed during gross necropsy (N = 37 female mice; WT Sham 11, L-RKO Sham 9, WT OVX 10, L-RKO OVX 7; Supplementary file 1). (B) Kaplan-Meier plot of the survival of female mice in which cancer was not observed during gross necropsy (N = 36 female mice; WT Sham 11, L-RKO Sham 8, WT OVX 7, L-RKO OVX 10; Supplementary file 1). (C) Kaplan-Meier plot of the survival of female mice lacking hepatic Rictor (L-RKO) and their wild-type (WT) littermates. All mice were subjected to gonadectomy (OVX) or Sham surgery at 3 weeks of age (N = 115 female mice; WT Sham 31, L-RKO Sham 29, WT OVX 27, L-RKO OVX 28; Supplementary file 1). (A–C) The overall effect of genotype (RKO), gonadectomy (OVX), and the interaction was determined using a Cox-proportional hazards test (HR, hazard ratio). The two-sided log-rank sum p-value was then calculated comparing individual curves for effects identified as significant in the regression analysis, and corrected for multiple comparisons (Holm-Sidak).